Pituitary carcinoma: reclassification and implications in the NET schema

The entity known as pituitary carcinoma has been traditionally defined a tumor of adenohypophysial cells that metastasizes systemically or craniospinally independent the histological appearance lesion. Reported cases have clinically and histologically resembled their non-metastatic counterparts were classified adenomas; majority initially diagnosed adenomas, with progression spread, diagnosis was changed to carcinoma. This classification challenged since definition malignancy in most organs is not based only on metastatic spread. extent local invasion resulting an inability completely resect can serious consequences cause harm are therefore benign. To address this dilemma, it proposed tumors be neuroendocrine tumors. change nomenclature totally appropriate these composed classical cells; other tumors, they variable behavior indolent but involve metastasis. With new nomenclature, there no requirement for distinction between adenomas carcinomas. Moreover, WHO/IARC provided overarching neoplasms at all body sites; classification, term ‘neuroendocrine carcinoma’ reserved poorly differentiated high-grade malignancies clinically, morphologically genetically distinct from well-differentiated It remains determined if true